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Updated: 47 weeks 5 days ago
Researchers at The University of Texas MD Anderson Cancer Center have announced a new method for detecting DNA mutations in a single cancer cell versus current technology that analyzes millions of cells which they believe could have important applications for cancer diagnosis and treatment. The results are published in the April 18 online issue of Nature Methods.
If genes form the body's blueprint, then the layer of epigenetics decides which parts of the plan get built. Unfortunately, many cancers hijack epigenetics to modulate the expression of genes, thus promoting cancer growth and survival. A team of researchers led by Tatiana Kutateladze, PhD, University of Colorado Cancer Center investigator and professor in the Department of Pharmacology at the University of Colorado School of Medicine, and Brian Strahl, PhD, professor in the Department of Biochemistry & Biophysics at the University of North Carolina School of Medicine, published a breakthrough report in the journal Nature Chemical Biology describing the essential role of YEATS domain proteins in reading epigenetic marks that regulate gene expression, DNA damage response, and other vital DNA-dependent cellular processes. This newly discovered player in epigenetic regulation is closely related to known cancer promoters, including the bromodomain proteins, a handful of which are targeted in current human clinical trials.
This is a phylogenetic tree constructed from nucleotide data from 41 viral complete ORF sequences of ZIKV strains An analysis comparing the individual differences between over 40 strains of Zika virus (30 isolated from humans, 10 from mosquitoes, and 1 from monkeys) has identified significant changes in both amino acid and nucleotide sequences during the past half-century. The data, published April 15 in Cell Host & Microbe, support a strong divergence between the Asian and African lineages as well as human and mosquito isolates of the virus, and will likely be helpful as researchers flush out how a relatively unknown pathogen led to the current outbreak.
A study by researchers from Inserm, the Paris Public Hospitals (Bichat Hospital, AP-HP), Aix-Marseille University, and the National Reference Centre for Arboviruses confirms that the ZIKA virus can be transmitted sexually. Their analyses have shown 100% genetic correlation between the form of the virus present in a man who contracted the virus in Brazil and that of a woman who had never travelled in the epidemic area, but who had sexual relations with him. These results are published in The New England Journal of medicine.
Queen and worker ants develop from the same sets of genes, but end up being structurally, behaviourally, and functionally different. Queen and worker ants develop from the same sets of genes, but perform completely different ecological roles. How the same genes result in two types of individuals is an ongoing mystery. In the past, scientists have only studied a small number of ant species at a time to try to understand the nature of queen-worker differences. However, a team from the Okinawa Institute of Science and Technology Graduate University (OIST) in tandem with the University of Helsinki and other collaborators from around the world, recently looked at a large data set with 16 species that provides insight into the differences between queen and worker ants.
Studies in a group of tropical birds have revealed one of the fastest limb muscles on record for any animal with a backbone. The muscle, which can move the wing at more than twice the speeds required for flying, has evolved in association with extravagant courtship displays that involve rapid limb movements, according to a paper to be published in the journal eLife.
Despite having policies in place to prevent infections, staff at outpatient care facilities fail to follow recommendations for hand hygiene 37 percent of the time, and for safe injection practices 33 percent of the time, according to a study published in the April issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC).
All the movies, images, emails and other digital data from more than 600 basic smartphones (10,000 gigabytes) can be stored in this faint pink smear of DNA. Technology companies routinely build sprawling data centers to store all the baby pictures, financial transactions, funny cat videos and email messages its users hoard.
Scientists from Penn Medicine and other institutions unlock a mystery about 'long non-coding RNAs'. A new genetic clue discovered by a team co-led by a researcher at the Perelman School of Medicine at the University of Pennsylvania is shedding light on the functions of the mysterious "long non-coding RNAs" (lncRNAs). These molecules are transcribed from genes and are often abundant in cells, yet they do not code for proteins. Their functions have been almost entirely unknown--and in recent years have attracted much research and debate.
The pace of evolution is typically measured in millions of years, as random, individual mutations accumulate over generations, but researchers at Cornell and Bar-Ilan Universities have uncovered a new mechanism for mutation in primates that is rapid, coordinated, and aggressive. The discovery raises questions about the accuracy of using the more typical mutation process as an estimate to date when two species diverged, as well as the extent to which this and related enzymes played a role in primate evolution.
The University of Georgia and Ben-Gurion University research team site-specifically inserted a small molecule named coralyne into the DNA and were able to create a single-molecule diode Researchers at the University of Georgia and at Ben-Gurion University in Israel have demonstrated for the first time that nanoscale electronic components can be made from single DNA molecules. Their study, published in the journal Nature Chemistry, represents a promising advance in the search for a replacement for the silicon chip.
This is an oyster at Whiskey Creek Shellfish Hatchery in Netarts Bay, Oregon. The ocean chemistry along the West Coast of North America is changing rapidly because of global carbon dioxide emissions, and the governments of Oregon, California, Washington and British Columbia can take actions now to offset and mitigate the effects of these changes.